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LATERAL FLOW
Lateral Flow
In-Line Technologies
 
     
     
 
More on LAMINATING TECHNOLOGIES
The roller pressure is adjustable up to 40 psi. The Membrane Feed module is used to feed backed or un-backed membrane for lamination to the plastic backing with adhesive. The station also includes take-up reels for the membrane liners and for adhesive release liners. This module provides for precision tension control and guidance of the membrane while being laminated onto the plastic backing. The module includes a pneumatically controlled lamination roller. The roller pressure is adjustable up to 40 psi. The Dispenser module is used to dispense onto the web at some point in the lamination process. A typical application would be to dispense lines onto the membrane after lamination. The module can accommodate up to 8 dispense heads which could be either BioJet or AirJet dispensers. Each dispenser can be configured with an inspection/mark system. This module is equipped with an ionizer to eliminate static charge build-up on the membrane prior to dispensing. The Drive Capstan module consists of a pneumatically controlled pinch roller which is used to move the web through the system. The pinch roller speed is variable from 1-100 mm/sec. The roller pressure is also adjustable up to 40 psi.

A Cutter/Dancer module can also be configured into the Automated Laminator system. This module provides an option for cutting the web into individual strips that are collected in a chute. The dancer is used as a buffer for the cut process that momentarily stops the web motion at the cut position. The dancer radii are maintained at 50 mm (2") to minimize bending stress. The cutter is a guillotine type that has a collection chute configured to receive the cut strips. A cut strip length is generally in the range of 300 to 1500 mm in length. If re-reeling the laminate is needed a Take-up Reel module can be configured. This module is used when the lamination is thin enough so as not to damage any of the layers with bending stresses generated by re-rolling. A Vision/Inspection Mark module can also be configured and consists of a vision camera with a marker system to inspect the laminate. Two inspections are performed. The first is for mechanical alignment of different layers. The second inspection is for marks from previous process steps. In the latter case a final mark is placed on the membrane which can be machine read at the final cut and assembly stage. A final module that can be incorporated is a Punching module. The Punching module consists of a die punch with a cam actuator and a pressurized pinch roller. The die punch is used to punch simple hole configurations such as circles, squares prior to lamination processes.

The types of tests formats would include immunoassays based on the lateral flow format or dry chemistry formats using treated pads laminated to a plastic backing. A typical application would be the lamination of a rapid diagnostic test strip or urine test strip. After lamination is complete, other processes can be performed such as addition of impregnation steps, additional lamination and/or cutting of the lamination into final test strips.

 
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