Karyotyping

The dropping process has remained a highly manual technique for years, leaving an automation void between harvesters and microscopes. CellWriter™ Workstations close the gap by automating the dropping process, delivering quality spread interphase and metaphase nuclei for analysis.

CellWriter technology:

  • Automates slide preparation
  • Decreases processing time
  • Improves metaphase consistency
  • Improves temperature, humidity and dropping control conditions
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Improved Consistency

CellWriter achieves chromosome spreading in a totally unique way. Rather than dispensing large droplets on a slide, BioDot prints an array of droplets at high speeds across the entire slide surface. This gives incredible control and consistency from sample to sample and slide to slide.

Karyotyping Products

Karyotyping
System
Dispense Channels
Slides per Batch
Samples per Batch
Probe / DAPI Vials per Batch
Barcode Scanning
Normalization
Denture / Hybridization
Coverslip Placement
CellWriter™ S
CellWriter™ S
1
Up to 24
Up to 24
Up to 48
Linear (All Standard Formats), 2D (Data Matrix, QR), Stacked (PDF417, GS1 Databar)
Yes
Yes
Yes
CellWriter™ 960
CellWriter™ 960
4
Up to 96
Up to 96
Up to 48
Linear (All Standard Formats), 2D (Data Matrix, QR), Stacked (PDF417, GS1 Databar)
Yes
Yes
Yes
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ChromoPrint™ Technology

The BioJet from BioDot is a highly refined biological printer that allows labs to “print” samples to slides with unparalleled control and consistency, using individual nanoliter droplets as the smallest feature size. Drop spacing, number of drops in both directions and drop size is adjustable, creating ideal pattern and spreading conditions.

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Cell Concentration Normalization

Nuclei spreading is a function of cell concentration, slide temperature and the relative humidity in the air space next to the slide. CellWriter Workstations provide control over temperature and humidity during the cell deposition process and measure the cell concentration of each sample in real-time, adjusting concentration prior to dispensing cells onto the slide surface. This results in highly consistent concentration and spreading.

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Related Applications